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Understanding Bioidentical Hormone Replacement Therapy BHRT and Its Benefits

Updated: Dec 16, 2025

What is BHRT? Understanding Bioidentical Hormone Replacement Therapy



Bioidentical Hormone Replacement Therapy (BHRT) is a treatment that supplements the natural hormones our bodies produce. As we age, hormone levels decline, leading to various health issues. By replacing these lost hormones, we can potentially prevent or correct age-related conditions.


Bioidentical hormones are not the same as synthetic hormones, which are derived from animals, like horses. Although animal hormones share some similarities with human hormones, they differ at the molecular level. These differences can have unknown effects on human health. Therefore, it is crucial to distinguish between synthetic and bioidentical hormones.


Bioidentical hormones are derived from natural sources, such as yams and soy. They are modified in laboratories to match the hormones produced by human endocrine glands. Many experts believe that bioidentical hormones are safer alternatives to synthetic options.


Despite common misconceptions about hormone therapies being harmful, extensive research supports the use of BHRT for treating and preventing chronic diseases. Replacing hormones that keep individuals healthy during their younger years may help delay or even reverse age-related issues like osteoporosis, dementia, heart disease, and weight gain.


Benefits of Hormone Replacement for Patients


1. Improves Cardiovascular Markers


A recent meta-analysis published in The Journal of North American Menopause Society in 2022 reviewed 29 randomized controlled trials involving nearly 2,000 perimenopausal and menopausal women. The study concluded that compounded hormones did not significantly alter lipid profiles or glucose metabolism, both of which are precursors to cardiovascular disease. The findings indicate that compounded hormones are effective and safe.


The literature highlights several cardiovascular benefits associated with hormone replacement therapy:


  • Higher serum free testosterone levels are linked to a reduced risk of carotid atherosclerosis in diabetic men.

  • Testosterone replacement therapy can effectively treat androgen deficiency in men, reducing fat mass, which is a contributor to cardiovascular disease.

  • A year-long study demonstrated that combining testosterone replacement therapy with diet and exercise significantly improved metabolic syndrome markers in newly diagnosed diabetic men.


Hormone replacement therapy may also reduce the risk of coronary heart disease (CHD) in women. Even when started later in life, oral estradiol can decrease insulin resistance without inducing plaque rupture.


2. Prevents and Treats Osteoporosis


Osteoporosis is a significant health concern, especially among the elderly. Research indicates that between 14% and 58% of elderly individuals who suffer a hip fracture may die within a year. However, osteoporosis is not an inevitable part of aging.


Studies have shown that DHEA replacement can significantly increase hip bone mineral density in older adults. Furthermore, estrogen deficiency is a leading cause of osteoporosis in both men and women. Discontinuing estrogen can rapidly diminish hip fracture protection.


Osteoporosis also negatively affects dental health, increasing the risk of tooth loss and periodontitis. Research indicates that estrogen replacement users experience significantly less tooth loss compared to non-users.


3. Supports Mental and Brain Health


Hormonal balance is crucial for mental and brain health in both genders. For men with androgen deficiency, testosterone replacement therapy can address psychological effects. Research has shown that lower testosterone levels correlate with poorer cognitive function. Higher testosterone levels are associated with improved cognitive performance.


Additionally, estrogen-containing hormone therapy may protect younger women from Alzheimer's disease or reduce the risk of early onset. Using hormone therapy during early postmenopause may also lower Alzheimer's risk.


4. Treats Subclinical Hypothyroidism


Many patients suffer from subclinical hypothyroidism, often characterized by symptoms of low thyroid function despite normal TSH levels. This condition can lead to metabolic syndrome and other health issues.


Unlike conventional therapies that only address primary hypothyroidism, hormone replacement therapy can treat subclinical forms. This opens doors for patients who may not respond to standard treatments. Desiccated thyroid, which provides T4, T3, and other thyroid hormones, has shown promise in improving thyroid function.


5. Improves Sexual Function


Aging often leads to a decline in sexual function for both men and women due to hormonal changes. For women, approaching menopause can result in vaginal atrophy and dryness, making intimacy painful. Hormone replacement therapy can effectively treat these conditions.


A 2022 meta-analysis found that compounded vaginal androgen significantly improved symptoms of vaginal atrophy and enhanced female sexual function scores. For men, testosterone replacement therapy can address erectile dysfunction and decreased libido associated with androgen deficiency.


Thyroid deficiency can also lead to sexual dysfunction in men. Research indicates that treating underlying thyroid issues may benefit men suffering from erectile dysfunction.


Improve Your Health with BHRT


Bioidentical hormones offer numerous benefits for patients. The advantages discussed above provide a high-level overview of how hormones can positively impact various systems in the body, including the heart, skin, bones, sex organs, and brain.


In conclusion, BHRT presents a viable option for those looking to improve their health and well-being. It is essential to consult with a healthcare professional to determine if this therapy is suitable for individual needs.


Sources

  1. Liu, PharmD, PhD, Yi, et al. Safety and Efficacy of Compounded Bioidentical Hormone Therapy (CBHT) in Perimenopausal and Postmenopausal Women: a Systematic Review and Meta-Analysis of Randomized Controlled Trials. Wolters Kluwer Health, Inc. on Behalf of The North American Menopause Society., 2022.

  2. Fukui M, Kitagawa Y, Nakamura N, et al. Association between serum testosterone concentration and carotid atherosclerosis in men with type 2 diabetes. Diabetes care. 2003;26(6):1869-1873. doi:10.2337/diacare.26.6.1869

  3. Winters SJ. Current status of testosterone replacement therapy in men. Archives of family medicine. 1999;8(3):257-263. doi:10.1001/archfami.8.3.257

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  5. Zyriax BC, Algenstaedt P, Hess UF, Schöffauer M, Bamberger C, Boeing H, Windler E. Factors contributing to the risk of cardiovascular disease reflected by plasma adiponectin: data from the coronary risk factors for atherosclerosis in women (CORA) study. Atherosclerosis. 2008 Oct;200(2):403-9. doi: 10.1016/j.atherosclerosis.2007.12.033. Epub 2008 Feb 8. PMID: 18262188.

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